Re: much wrong with this article -is she sponsored by big phama?
by
jafi
10/21/2009, 12:18 PM #
This study directly contradicts the assertion that vaccination does not prevent disease. The lower herd immunity threshold for pertussis is very high 92% - 94%. That means a small rate of non vaccination means more pertussis infections.
The study below establishes more data to support the contention that vaccines do matter. By your contention there should be no higher incidence of pertussis among non-vaccinated kids. This clearly isn't the case. There may be few deaths because of better medical care.
<link>
Published online May 26, 2009
PEDIATRICS
Vol. 123
No. 6
June 2009, pp.
1446-1451
(doi:10.1542/peds.2008-2150)
Parental Refusal of Pertussis Vaccination Is Associated With an Increased Risk of Pertussis Infection in Children
Jason M. Glanz, PhDa,b,
David L. McClure, PhDa,
David J. Magid, MD, MPHa,b,
Matthew F. Daley, MDa,c,d,
Eric K. France, MD, MSPHe,
Daniel A. Salmon, PhD, MPHf and
Simon J. Hambidge, MD, PhDa,b,d,g
a Institute for Health Research
e Department of Prevention, Kaiser Permanente Colorado, Denver, Colorado; Departments of
b Preventive Medicine and Biometrics
d Pediatrics, University of Colorado, Denver, Colorado
c Department of Pediatrics, Children's Hospital, Denver, Colorado
f Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
g Community Health Services, Denver Health, Denver, Colorado
OBJECTIVE. The objective of this study was to determine if children who
contracted pertussis infection were more likely to have parents who
refused pertussis vaccinations than a similar group of children who did
not develop pertussis infection.
METHODS. We conducted a case-control study of children enrolled in the
Kaiser Permanente of Colorado health plan between 1996 and 2007. Each
pertussis case was matched to 4 randomly selected controls. Pertussis
case status and vaccination status were ascertained by medical chart
review.
RESULTS. We identified 156 laboratory-confirmed pertussis cases and 595
matched controls. There were 18 (12%) pertussis vaccine refusers among
the cases and 3 (0.5%) pertussis vaccine refusers among the controls.
Children of parents who refused pertussis immunizations were at an
increased risk for pertussis compared with children of parents who
accepted vaccinations. In a secondary case-control analysis of children
continuously enrolled in Kaiser Permanente of Colorado from 2 to 20
months of age, vaccine refusal was associated with a similarly
increased risk of pertussis. In the entire Kaiser Permanente of
Colorado pediatric population, 11% of all pertussis cases were
attributed to parental vaccine refusal.
CONCLUSIONS. Children of parents who refuse pertussis immunizations are
at high risk for pertussis infection relative to vaccinated children.
Herd immunity does not seem to completely protect unvaccinated children
from pertussis. These findings stress the need to further understand
why parents refuse immunizations and to develop strategies for
conveying the risks and benefits of immunizations to parents more
effectively.
Key Words: immunizations • pertussis • vaccinations • vaccine refusal • epidemiology
Abbreviations:
KPCO—Kaiser Permanente Colorado • PCR—polymerase chain reaction •
OR—odds ratio • CI—confidence interval • URI—upper respiratory infection