There are several very reasonable legal and security applications for functional MR imaging, a painless and highly accurate methodology. These include interrogation for truth/ deception, adverse central nervous system effects of medications (depression, agitation, aggression, suicidal thought, drug-seeking), and development of cognitive impairment. Three companies have offered functional MR for interrogation. NoLieMRI and Cephos Corp use a rather artificial questioning structure and limit their work to yes/no questions. To effectively extract intelligence, a combination of scanning techniques must be used, to collect truth/deception signatures, but to also look for recognition of faces, objects and places, emotional states, and underlying structural integrity of the brain. Cognitive Engineering, LLC www.Cognitive-Eng.org employs this more robust approach, with application envisioned beyond criminal investigation, to include security investigations, pre-employment screening, national security, occupational suitability and effective mind reading protocols. Functional MR can be expected to be used with increasing frequency in the near future in interrogation, to identify brain alterations due to prescription medications, and to identify and quantitate cognitive impairment.