Sleazy personal attacks and extreme vulgarities should be off-limits, likewise attacks on the kids. Too many out there just want to hate, not deal with issues.
I think that the old notion of the First Lady/candidate's wife who sits around, looks pretty, and serves as Hostess is pretty much a thing of the past.
Hell, even Wilson's wife pretty much finished out his second term after he was incapacitated. And how could FDR have managed without Eleanor?
It's a partnership.