Statistically male homosexuality is roughly 11% of the population. That means that in an immediate family of a Father with a brother, a sister and 2 sons, and a mother with a brother and a sister, you have 5 men. Statistically that means there is a 56% chance that there are no gay homosexuals in that family assuming there is no genetic driver.
If there is a genetic driver then it gets more complicated, especially if it is maternally driven and I'm not going to bother doing the numbers, but it ends up that its not at all unlikely.