If I have time to read Prudie and respond early in the game I may do so, but only if I feel like I have something useful or hopefully entertaining to offer. If I don't feel like I have anything to offer I try (really hard) to STFU.
If someone posts something inane, goofy, or outrageously stupid, I will either try to aggravate them further or I might try to load them down with relevant or irrelevant questions about their post.
If a post turns away from the original topic, I am glad to discuss cats, gardening, movies, or dirty jokes.